Potential Influence of NUCB2 Genetic Variants on the Clinicopathological Features of Patients with Hepatocellular Carcinoma

Background

Hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer type worldwide in males and the ninth among females, and it is a primary cause of cancer-associated death. The adipokine nesfatin-1, initially discovered in hypothalamic neurons, is produced by the precursor NUCB2 gene. The relationship between NUCB2 polymorphisms, behavioral risk factors that facilitate cancer, and HCC is still unknown.