Prognostic Significance of p53 Immunohistochemical Expression and Molecular Characterization of TP53 Variants in Triple-Negative Breast Cancer After Neoadjuvant Chemotherapy

Background

The prognostic significance of p53 immunohistochemical expression in triple-negative breast cancer (TNBC) remains controversial, particularly following neoadjuvant chemotherapy (NAC). The relationship between p53 immunohistochemical expression, TP53 sequence variants, and clinical outcome following neoadjuvant chemotherapy remains incompletely understood. This study evaluated the relationship between p53 expression, TP53 variant profiles, longitudinal changes in TP53 variant detection and allele frequency, and clinical outcome in patients with TNBC treated with NAC.