Early Serum S100B and Neurophysiological and Structural Brain Abnormalities in a Prospective Cohort of Preterm Infants

Background

Early identification of brain dysfunction in preterm infants remains challenging because cranial ultrasonography (CUS) may not capture early neurophysiological abnormalities. Serum S100B has been proposed as a marker of neonatal brain injury, but its relationship with electroencephalographic (EEG) abnormalities in preterm infants remains unclear.