Children
Claims-Based Diagnostic Registration Patterns and Clinical Burden of Selected Common Aneuploidies in Korean Children: A Nationwide HIRA Study (2009–2023)
Par Hye Eun Kwon, SO-HYEON GWON, Nak-Hoon Son et 1 autres.
Contenu en anglais
Résumé
Background
Selected common aneuploidies, including Down, Edwards, Patau, Turner, and Klinefelter syndromes, are important causes of congenital anomalies and diverse clinical morbidities. However, nationwide evidence regarding the recent diagnostic registration patterns, clinical outcomes, and healthcare burdens in South Korea remains limited.
Methods
We conducted a nationwide descriptive analysis using claims data from the Health Insurance Review and Assessment Service (HIRA) of South Korea between 2009 and 2023. Among individuals aged 0–14 years, we evaluated period-based administrative registration frequency and ratios relative to live births, age at diagnosis, comorbidities including congenital heart disease (CHD) and epilepsy, in-hospital mortality, and first-year healthcare expenditures following the first observed claims-code date.