Metastasis-Directed Therapy Versus Systemic Therapy in Oligometastatic Endometrial Carcinoma Recurrence: A Population-Based Registry Analysis

Background/Objectives: Comparative data on metastasis-directed therapy (MDT) versus systemic therapy in oligometastatic endometrial carcinoma (EC) recurrence are lacking.

Methods

In this retrospective population-based registry study (Tumor Register Saxony-Anhalt, 2000–2025), we included 153 treated patients with distant-only oligometastatic EC recurrence (≤2 anatomical sites) after curative-intent primary treatment. Overall survival (OS) was compared between a strategy including MDT (n = 97) and systemic therapy alone (n = 56) using inverse probability of treatment weighting (IPTW)-adjusted Cox regression. Subgroup, sensitivity and competing risks analyses were exploratory.