YY1 Suppresses Tumor Growth by Negatively Regulating the Expression and Translation Activity of eIF4E in Nasopharyngeal Carcinoma

Background

Nasopharyngeal carcinoma (NPC) is a complex malignancy, and the molecular mechanisms that drive its progression have not yet been fully elucidated. Eukaryotic translation initiation factor 4E (eIF4E), a pivotal regulator of protein synthesis, is frequently dysregulated in cancers. We previously identified eIF4E as a direct transcriptional target of Yin Yang 1 (YY1) in an axis where YY1 suppressed NPC invasion and metastasis.