Diffusion MRI Markers of Symptom Interference and Survival in Head and Neck Cancer Survivors

Background

Diffusion MRI (dMRI) provides sensitive markers of brain microstructure and glymphatic function. The interplay between brain microstructure and glymphatic function in shaping long-term survivorship outcomes remains unclear. We examined associations of dMRI markers with survival and symptom interference in long-term head and neck (HN) cancer survivors and tested whether glymphatic function modified these associations.