Preprints.org
Case Series Analysis of Five Rare Cases of Hyperprolactinemia in Diabetes Mellitus: Clinical Characteristics, Molecular Pathways, and Implications for Targeted Management
Par El-Nagar AA, Kenawy AM et Karam M.
Contenu en anglais
Résumé
Background
Hyperprolactinemia, characterized by serum prolactin levels >20 ng/mL, is a rare comorbidity in diabetes mellitus, potentially exacerbating insulin resistance and glycemic dysregulation via JAK/STAT signaling. This case series analysis examines five rare cases to elucidate clinical patterns, molecular mechanisms, and therapeutic outcomes, aiming to inform precision endocrine management.
Methods
Five cases were curated from PubMed and Scopus (1999–2025), focusing on hyperprolactinemia in diabetes (type 1, type 2, or insipidus). Data on demographics, symptoms, laboratory findings (prolactin, insulin, C-peptide), imaging (MRI), and treatment outcomes were extracted.