Investigative Ophthalmology & Visual Science
Surface-Specific Internal Limiting Membrane Biomechanics in Epiretinal Membrane Severity and Visual Outcomes
Par Changsik Yoon, Sangkyung Choi, 윤예슬 et 4 autres.
Contenu en anglais
Résumé
Purpose
To determine whether surface-specific biophysical properties of the internal limiting membrane (ILM), measured by atomic force microscopy (AFM), are associated with optical coherence tomography (OCT)–based epiretinal membrane (ERM) stage and six-month visual outcomes.
Methods
In this prospective study, ILM specimens from vitrectomy for idiopathic ERM (stages 2–4) were examined by AFM for thickness, roughness, stiffness, and adhesion on the vitreal or retinal surface. AFM parameters were related to preoperative OCT parameters, best-corrected visual acuity, surgical grade of ILM adherence, and six-month outcomes. Multivariable regression assessed correlates of visual change and final acuity.