Activation of SIRT6 Using a Hydrolyzed Yeast Protein Extract to Enhance Skin Longevity by Targeting Multiple Hallmarks of Aging

Introduction

Photoaging and chronological age-related changes in cellular functioning such as telomere attrition can lead to accumulation of senescent skin cells, a key driver of age-related decline in skin integrity and function. Activation of sirtuins (SIRTs), master epigenetic regulators of cellular functioning and homeostasis in skin, may be a promising approach to protect skin cells from the effects of photoaging and cellular hallmarks of skin aging.