Pulse
Discordance between Carotid-Femoral and Brachial-Ankle Pulse Wave Velocity in Identifying Elevated Central Arterial Stiffness
Par Yonghui Wang, Guorui Liang, qian yang et 4 autres.
Contenu en anglais
Résumé
Introduction
Carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) are both used to assess arterial stiffness, but their agreement in identifying elevated central arterial stiffness remains uncertain.
Methods
This prospective observational study included 222 adults who underwent standardized baseline vascular function testing. The primary phenotype analysis included 205 participants with available cfPWV, maximum bilateral baPWV (baPWVmax), and minimum ankle-brachial index data. Elevated central arterial stiffness was defined as cfPWV ≥10 m/s and elevated baPWV as baPWVmax ≥14 m/s. Associations between cfPWV and baPWVmax were assessed using Spearman correlation and residual correlation after adjustment for age, sex, and systolic blood pressure. Threshold agreement, receiver operating characteristic analysis, and alternative baPWVmax thresholds were evaluated.