Gynecologic and Obstetric Investigation
Papaverine administration during labor induction in nulliparous patients: a retrospective cohort study
Par Raneen Abu Shqara, Nadir Ganem, ala aiob et 3 autres.
Contenu en anglais
Résumé
Objectives
To evaluate the association between papaverine administration during labor induction and maternal and neonatal outcomes among nulliparous patients, with particular emphasis on cesarean delivery, labor duration, and timing of administration relative to rupture of membranes.
Design
Retrospective cohort study. Participants/Materials: The study included 1,889 nulliparous patients with singleton pregnancies who underwent medically indicated labor induction with intravenous oxytocin between January 2020 and December 2024. Patients were categorized according to papaverine exposure: no papaverine (n=1,185), one 80-mg intramuscular dose (n=618), or two 80-mg intramuscular doses (n=86).