Acetaminophen Use in Pregnancy: Evidence, Controversies, and Clinical Counseling

Objective

To review the current evidence regarding acetaminophen use in pregnancy, evaluate reported associations with adverse neurodevelopmental and reproductive outcomes, and provide an evidence-based framework for clinical counseling and decision-making. Study Design: A narrative review of the literature was performed, emphasizing large observational cohort studies, sibling-comparison analyses, pharmacokinetic data, and recent systematic reviews evaluating prenatal acetaminophen exposure and maternal-fetal outcomes.