American Journal of Preventive Cardiology
Genetically determined very low lipoprotein(a) is not associated with type 2 diabetes and glycemic traits
Par Moa P. Lee, Paulina Baca, Fernando Rivas et 11 autres.
Contenu en anglais
Résumé
Background
Lipoprotein (a) [Lp(a)] is an independent atherosclerotic cardiovascular disease risk factor, with levels largely determined by variation in the LPA gene. Despite interests in therapeutic Lp(a) lowering, the phenotypic effects of very low Lp(a) are incompletely characterized, with some studies suggesting increased type 2 diabetes risk.
Objectives
Estimate associations between very low Lp(a), inferred by LPA loss of function variant rs41272114, with type 2 diabetes and glycemic biomarkers.
Methods
A multi-population study of European, Hispanic/Latino, and South Asian populations from five cohort studies was assembled. Effects of the null allele rs41272114 (CC, wild-type; T, null allele) on type 2 diabetes and glycemic biomarkers (fasting glucose, fasting insulin, glycosylated hemoglobin (HbA1c), triglyceride-to-high-density lipoprotein ratio, and HOMA-IR) were estimated using multivariable-adjusted and cohort-specific linear or logistic regression models that were combined using inverse variance meta-analysis.