Sex-specific associations of social determinants of health and genetic risk factors with atherosclerotic cardiovascular diseases incidence in the general population

Background and aims: The combined contribution of social determinants of health (SDOH) that includes socioeconomic status, psychosocial factors and living environment and genetic background on atherosclerotic cardiovascular disease (ASCVD) risk remains unknown. We investigated the contribution of a polysocial risk score (PSS) and polygenic risk scores (PRS) on ASCVD incidence.