Bedside monitoring of the vascular response to norepinephrine in early septic shock: VNERi trajectories and comparison with dynamic clinical measures

Abstract Purpose: The vascular norepinephrine response index [VNERi = diastolic arterial pressure / (norepinephrine dose × heart rate)] is a bedside index computed from already-monitored signals. It has been studied only at baseline. We described its 48-hour course and tested whether it adds prognostic information beyond dynamic clinical measures.