Liver enzyme elevations during statin-ezetimibe therapy in ABCG2 c.421C>A variant carriers: a case series and narrative review

Introduction

Statin-ezetimibe combination therapy is widely used and generally well tolerated; however, liver enzyme elevations may occur during treatment and can be difficult to interpret in patients with polypharmacy and other contributing factors. The potential role of drug-drug-gene interactions (DDGIs) in this context remains insufficiently explored.

Materials and methods