Potential Drug-Drug Interactions in Critically Ill Neonates: Association With Clinical Outcomes in a Prospective Cohort

Background and aims: Neonates admitted to neonatal intensive care units (NICUs) are frequently exposed to multiple medications, increasing the risk of potential drug-drug interactions (pDDIs). However, the clinical impact of these interactions remains poorly understood in this population. This study aimed to evaluate the occurrence of pDDIs in critically ill neonates and their association with clinical outcomes and laboratory parameters.