CLSP-REQA: a real-time quality-aware closed-loop seizure prediction framework with Mamba-BiLSTM and confidence-gated intervention

Introduction

Reliable seizure prediction is a prerequisite for closed-loop neurostimulation therapy, yet existing methods rarely account for the variability in EEG signal quality encountered in real-world deployment, and the overwhelming majority adopt non-strict evaluation protocols that overestimate generalization performance.