Allostatic Load and Severe Clinical Phenotypes in Major Depressive Disorder: A Cross-Sectional Statistical Mediation Analysis of Perceived Stress, Cognitive Impairment, and Suicidal Ideation

Background

Perceived stress is associated with adverse clinical features of major depressive disorder (MDD), but the role of multisystem physiological dysregulation remains uncertain. We examined whether allostatic load (AL) was statistically associated with the relationship between perceived stress and cognitive impairment or severe suicidal ideation.