Journal of diabetes investigation
Fasting proinsulin as a predictor of future glucose tolerance deterioration in Japanese adults
Von Kajihara N, Tsuyama T, Fukuda K und 4 weiteren.
Inhalt auf Englisch
Abstract
Aims/introduction
Proinsulin is associated with β-cell stress and has been linked to subsequent deterioration in glucose metabolism in Western populations, but its predictive value in Asian populations remains unclear. We investigated whether proinsulin is associated with future glucose tolerance deterioration in community-dwelling Japanese adults.
Materials and methods
Of 160 individuals who underwent a 75-g oral glucose tolerance test (OGTT) in 2020-2021, 88 completed a follow-up OGTT in 2024-2025. Fasting proinsulin concentrations were measured using stored baseline serum samples from 84 participants. Associations with glucose tolerance deterioration were examined using Firth's penalized logistic regression, and discriminatory performance was evaluated using receiver operating characteristic (ROC) analysis.