Drug metabolism and bioanalysis
Metabolomics Methods for Detecting Acetaminophen Poisoning: A Systematic Review
Von Murugesan T und Velmurugan H.
Inhalt auf Englisch
Abstract
Introduction
Detecting toxicity patterns in metabolic changes is a key indicator of potential threats. Metabolomics may provide an alternative way to find biomarkers for drug overdose and toxicity. In an acetaminophen overdose, glutathione scavenging causes mitochondrial malfunction and hepatocyte death. Metabolomics methods have enabled the discovery of novel mechanisms of liver injury in acetaminophen (APAP) overdose.