Impact of lipid accumulation product on cardiometabolic multimorbidity and the mediating effect of leukocytes: evidence from a prospective cohort study among middle-aged and elderly chinese adults

Background

Cardiometabolic multimorbidity (CMM) is a growing public-health burden in ageing populations, yet conventional adiposity measures such as body mass index and waist circumference do not adequately capture the visceral fat and lipid-metabolic disturbances that underlie it. We investigated the association between the lipid accumulation product (LAP) and incident CMM in middle-aged and older Chinese adults, and examined whether systemic inflammation mediates this association.