Biological effects of dental resin composites on human gingival fibroblasts: a systematic review of in vitro evidence

This systematic review summarized and synthesized the in vitro biological effects of resin composites (RCs) on human gingival fibroblasts (HGFs) to clarify their isolated cellular biocompatibility.

A systematic search was conducted in the MEDLINE/PubMed database using a PECOS framework to identify in vitro studies evaluating HGF responses to RCs. Two independent reviewers screened literature, extracted data, and assessed methodological quality (QUIN tool) and certainty of the evidence (GRADE framework).