Integrated Single-Cell and Bulk RNA Sequencing Reveals Inflammatory Microenvironment and Glycolysis-Driven Epithelial Proliferation in Benign Prostatic Hyperplasia

Background

Benign prostatic hyperplasia (BPH) is a prevalent condition and a leading cause of urinary dysfunction in middle-aged and elderly men. The hyperplasia of prostate stromal and epithelial cells enlarges the prostate, compressing the bladder outlet and resulting in obstructive symptoms. However, the crosstalk between the inflammatory microenvironment and metabolic alterations in BPH remains poorly understood.