Comparative efficacy of 200 units versus 155 units of onabotulinumtoxin a for chronic migraine

Background

Migraine is a common neurological condition; it can be classed as episodic or chronic. In chronic migraine (CM), one of therapies have been revealed efficacy is onabotulinumtoxin A (OnaBT-A). Aim of study: To confirm that the effect of OnaBT-A treatment is dose dependent for the treatment of CM Material and methods: This prospective, randomized, comparative study was carried out at a private neurological clinic in Mosul, Iraq. This study comprised a total of 106 patients who met the diagnostic criteria for CM. Two groups of patients were formed. The first group received 200 U of OnaBT-A by local injection, the second group received 155 U. Each group received OnaBT-A at the start of the trial, as well as after 12 weeks. The outcome indicators which include: monthly headache frequency, attack severity, duration of headaches, and disability, were collected and recorded at the baseline, at week 12 and at week 24.