Progress in rehabilitation medicine
Effect of Branched-Chain Amino Acid-enriched nutritional supplement after exercise on skeletal muscle mass in patients undergoing surgery for gastrointestinal cancer
Von Iwahashi M, Matsumoto T, Mori Y und 5 weiteren.
Inhalt auf Englisch
Abstract
Objectives
To investigate the effects of branched-chain amino acid (BCAA)-enriched nutritional supplementation after exercise on skeletal muscle and walking ability in patients undergoing gastrointestinal cancer surgery.
Methods
Fifty patients with gastric or colorectal cancer scheduled for surgery were enrolled in this single-center, single-blind, randomized controlled study. Patients were randomly assigned to a BCAA-enriched jelly group (test group) or an amino acid-free jelly group (control group). Both groups received perioperative exercise therapy and jelly supplementation immediately after exercise. The primary endpoints were percentage changes in thigh skeletal muscle area from pre-intervention to 9 weeks after discharge and from 2 weeks after surgery to 9 weeks after discharge. Secondary endpoints were changes in isometric knee extension and flexion strength and 6-minute walk distance.