Evaluation of Nephroprotective Activity of Eurycoma Longifolia Extract in Experimental Animal Model

Objective

To investigate the Nephroprotective activity of ethanol extract of Eurycoma Longifolia on Gentamicin induced Nephrotoxicity in male Wistar rats. Material & method: In this model of Nephrotoxicity, 30 adult male wistar rats (150-200gms) were evenly divided into 5 groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively, after each dose Gentamicin (80 mg/kg, i.p.) for 10 day . On 11 th day, blood samples for biochemical parameters, while the rats kidneys for histology were obtained under inhaled diether anaesthesia.