Pathogens
Pseudovirus Nanoparticles Displaying the Receptor-Binding Glycoprotein of Marburg Virus as Potential Vaccine Candidates
Von Ming Xia, Frank S. Vago und Ming Tan.
Inhalt auf Englisch
Abstract
Background
The lack of a licensed vaccine against the deadly Marburg virus (MARV) calls for the development of a novel and effective vaccine strategy.
Methods
We report here our development of three pseudovirus nanoparticles (PVNPs), each displaying a MARV-neutralizing glycoprotein (GP) segment of different lengths, as MARV vaccine candidates. These PVNPs, designated S-GP278, S-GP377, and S-GP486, were generated using our proprietary norovirus shell nanoparticle (SNP) platform. The PVNPs were evaluated for their production, self-assembly, morphology, structural properties, and immunogenicity.