Acute Effects of Caffeine on Choroidal Structure and Vascularity in Healthy Young Adults: A Time-Resolved OCT and OCT-Angiography Study

Background

Caffeine, the most widely consumed dietary bioactive compound worldwide, exerts acute vasoactive effects on several vascular beds, but its impact on the internal composition of the choroid remains unclear. We evaluated the acute effects of a single oral dose of caffeine on choroidal structure and vascularity, retinal superficial capillary plexus (SCP) microcirculation, optic nerve head (ONH) perfusion, and intraocular pressure (IOP) in healthy young adults.