Development and Initial Validation of a Statistical Image Analysis Framework for Quantitative Bone SPECT/CT in Patients with Prostate Cancer

Background/Objectives: Quantitative bone single-photon emission computed tomography/computed tomography (SPECT/CT) enables standardized uptake value (SUV)-based assessment of skeletal tracer uptake; however, SUV does not directly indicate the degree of deviation from the physiological distribution at the corresponding anatomical location. This study aimed to develop a statistical image analysis software framework for quantitative bone SPECT/CT and perform its initial validation.