Macrophage Density Patterns in Uterine Leiomyomas Across Patient Age Groups: Evaluation of Separately Quantified CD68-Positive and CD163-Positive Cells

Tumor-associated macrophages (TAMs), key effectors of the innate immune system, actively participate in extracellular matrix remodeling, angiogenesis, and tumor growth. However, their age-associated quantitative and phenotypic distribution in uterine leiomyoma microenvironment remains insufficiently understood. This study aims to evaluate the density and spatial distribution of CD68+ and CD163+ macrophage immunophenotypes in uterine leiomyoma stroma across distinct patient age groups.