Investigative Ophthalmology & Visual Science
Longitudinal Changes in Choroidal Thickness Across the Eye in Young Children With Premyopia
Von Karen Flores, Aidan McCullough, Zhihui She und 2 weiteren.
Inhalt auf Englisch
Abstract
Background
The choroid is thought to be implicated in eye growth regulation, yet longitudinal choroidal data in young children are limited.
Methods
Choroidal thickness (ChT) was measured in 92 children with functional emmetropia (baseline age, 7.4 ± 0.8 years; cycloplegic refractive error, +1.01 ± 0.55 diopters) enrolled in the 3-year PICNIC (Preventing Myopia: Investigating Contributing Factors to Nearsightedness in Children) study. Wide-field spectral domain OCT radial scans (12-line, enhanced depth imaging) were segmented using a neural network and sampled at annular eccentricities (1, 3, 6, 10, and 14 mm) in four quadrants (temporal, superior, nasal, and inferior). A generalized linear mixed model evaluated the effects of risk group (low risk vs. high risk, based on baseline hyperopic reserve and parental myopia), eccentricity, quadrant, visit, axial length (AXL), and age. A separate linear mixed model was used to assess the preonset ChT in children who developed myopia.