Mortality rates among adults with sepsis and septic shock in Indonesia: a systematic review and meta-analysis.

Abstract / Summary

Sepsis and septic shock represent a critical global health challenge, accounting for a substantial proportion of patient fatalities worldwide. Despite this, Indonesia lacks a comprehensive, nationwide analysis of the mortality rates associated with these conditions. This study aimed to systematically evaluate the burden of sepsis and septic shock mortality across Indonesia, addressing a crucial gap in the existing healthcare data, which may aid clinical and policy considerations. We searched PubMed, Scopus, DOAJ, and citation lists for studies with sepsis and septic shock mortality rate , focusing on 28-day and in-hospital mortality. Study quality was assessed using the Newcastle-Ottawa Scale, and the protocol was registered with PROSPERO (CRD42025645312). Overall, 47 studies were included in this review , revealing a pooled 28-day mortality rate of 55.9% (95% CI, 48.7%-63.0%; I2 = 79.5%) among patients with sepsis and septic shock, as determined by the Sepsis-3, Sepsis 2, and Not-Mentioned criteria. Additionally, the in-hospital mortality rates for the same cohort were higher at 67.4% (95% CI, 62.9%-72.0%; I2 = 95.02%). Notably, among patients with septic shock specifically, in-hospital mortality reached 77.5% (95% CI, 67.3%-87.8%; I2 = 91.18%). Sepsis and septic shock mortality rates in Indonesian adults remain high. These findings underscore the need for enhanced sepsis management protocols, effective resource allocation, and targeted interventions for vulnerable patients.

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